Dicalcium Phosphate or Calcium Phosphate or Calcium Hydrogen Phosphate Dibasic Dihydrate Anhydrous Specifications of Commercial Pure & BP Ph Eur USP FCC Food Grade Manufacturers & Exporters
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Dicalcium Phosphate or Calcium Phosphate Dibasic or Calcium Hydrogen Phosphate CAS Number 7757-93-9 for anhydrous & 7789-77-7 for dihydrate
Dibasic Calcium Phosphate Dihydrate USP Grade Specifications:
CaHPO4-2H2O --- 172.09
Phosphoric acid, calcium salt (1:1);
Calcium phosphate, dihydrate (1:1) CAS 7789-77-7
DEFINITION
Dibasic Calcium Phosphate Dihydrate contains two molecules of water of hydration. It contains NLT 98.0% and NMT 105.0% of dibasic calcium phosphate dihydrate (CaHPO4-2H2O).
IDENTIFICATION
A.
Sample: 0.1 g of Dibasic Calcium Phosphate Dihydrate
Analysis: Dissolve the Sample by warming in 10 mL of 2 N hydrochloric acid. Add 2.5 mL of ammonia dropwise, with shaking, and then add 5 mL of ammonium oxalate.
Acceptance criteria: A white precipitate is formed.
B.
Sample: 0.1 g of Dibasic Calcium Phosphate Dihydrate
Analysis: Dissolve the Sample in 5 mL of diluted nitric acid. Warm the solution to 70C and add 2 mL of 10% ammonium molybdate solution (freshly prepared).
Acceptance criteria: A yellow precipitate of ammonium phosphomolybdate is formed.
Carbonate:
Sample: 1.0 g of Dibasic Calcium Phosphate Dihydrate
Analysis: Mix the Sample with 5 mL of carbon dioxide-free water, and immediately add 2 mL of hydrochloric acid.
Acceptance criteria: No effervescence occurs.
Chloride and Sulfate, Chloride:
Standard: 0.70 mL of 0.010 N hydrochloric acid
Sample: 0.2 g of of Dibasic Calcium Phosphate Dihydrate
Analysis: To the Sample add 20 mL of water and 13 mL of diluted nitric acid, and warm gently, if necessary, to completely dissolve. Dilute with water to 100 mL, and filter if necessary. To 50 mL of the filtrate add 1 mL of silver nitrate.
Acceptance criteria: The turbidity of the Sample does not exceed that of the Standard (NMT 0.25%).
Chloride and Sulfate, Sulfate:
Standard: 1.0 mL of 0.010 N sulfuric acid
Sample: 0.5 g of Dibasic Calcium Phosphate Dihydrate
Analysis: To the Sample add 5 mL of water and 5 mL of diluted hydrochloric acid, and warm gently, if necessary, to completely dissolve. Dilute with water to 100 mL, and filter if necessary. To 20 mL of the filtrate add 1 mL of diluted hydrochloric acid and dilute with water to 50 mL. Add 1 mL of barium chloride.
Acceptance criteria: The turbidity of the Sample does not exceed that of the Standard (NMT 0.5%).
Arsenic: To pass the test. --- NMT 3 µg/g
Barium:
Sample: 0.5 g Dibasic Calcium Phosphate Dihydrate
Analysis: Heat the Sample to boiling with 10 mL of water, and add 1 mL of hydrochloric acid dropwise, stirring after each addition. Allow to cool, and filter, if necessary. To the filtrate add 2 mL of potassium sulfate.
Acceptance criteria: No turbidity is produced within 10 min.
Limit of Acid-Insoluble Substances: To pass the test. --- (NMT 0.2%).
Limit of Fluoride: To pass the test. --- NMT 50 ppm
Loss on Ignition: Sample: 1 g of Dibasic Calcium Phosphate Dihydrate
Analysis: Ignite the Sample at 800C to 825C to constant weight.
Acceptance criteria: 24.5% to 26.5%
Anhydrous Dibasic Calcium Phosphate USP Grade Specifications:
CaHPO4 --- 136.06
Phosphoric acid, calcium salt (1:1);
Calcium phosphate (1:1) CAS 7757-93-9
DEFINITION
Anhydrous Dibasic Calcium Phosphate contains NLT 98.0% and NMT 103.0% of anhydrous dibasic calcium phosphate (CaHPO4).
IDENTIFICATION
A.
Sample: 0.1 g of Anhydrous Dibasic Calcium Phosphate
Analysis: Dissolve the Sample by warming in 10 mL of 2 N hydrochloric acid. Add 2.5 mL of ammonia dropwise, with shaking, and then add 5 mL of ammonium oxalate.
Acceptance criteria: A white precipitate is formed.
B.
Sample: 0.1 g of Anhydrous Dibasic Calcium Phosphate
Analysis: Dissolve the Sample in 5 mL of diluted nitric acid. Warm the solution to 70C and add 2 mL of 10% ammonium molybdate solution (freshly prepared).
Acceptance criteria: A yellow precipitate of ammonium phosphomolybdate is formed.
Carbonate:
Sample: 1.0 g of Anhydrous Dibasic Calcium Phosphate
Analysis: Mix the Sample with 5 mL of carbon dioxide-free water, and immediately add 2 mL of hydrochloric acid.
Acceptance criteria: No effervescence occurs.
Chloride and Sulfate, Chloride:
Standard: 0.70 mL of 0.010 N hydrochloric acid
Sample: 0.2 g of Anhydrous Dibasic Calcium Phosphate
Analysis: To the Sample add 20 mL of water and 13 mL of diluted nitric acid, and warm gently, if necessary, to completely dissolve. Dilute with water to 100 mL, and filter if necessary. To 50 mL of the filtrate add 1 mL of silver nitrate.
Acceptance criteria: The turbidity of the Sample does not exceed that of the Standard (NMT 0.25%).
Chloride and Sulfate, Sulfate:
Standard: 1.0 mL of 0.010 N sulfuric acid
Sample: 0.5 g of Anhydrous Dibasic Calcium Phosphate
Analysis: To the Sample add 5 mL of water and 5 mL of diluted hydrochloric acid, and warm gently, if necessary, to completely dissolve. Dilute with water to 100 mL, and filter if necessary. To 20 mL of the filtrate add 1 mL of diluted hydrochloric acid and dilute with water to 50 mL. Add 1 mL of barium chloride.
Acceptance criteria: The turbidity of the Sample does not exceed that of the Standard (NMT 0.5%).
Arsenic: To pass the test. --- NMT 3 µg/g
Barium:
Sample: 0.5 g Anhydrous Dibasic Calcium Phosphate
Analysis: Heat the Sample to boiling with 10 mL of water, and add 1 mL of hydrochloric acid dropwise, stirring after each addition. Allow to cool, and filter if necessary. To the filtrate add 2 mL of potassium sulfate.
Acceptance criteria: No turbidity is produced within 10 min.
Limit of Acid-Insoluble Substances: To pass the test. --- (NMT 0.2%).
Limit of Fluoride: To pass the test. --- NMT 50 ppm
Loss on Ignition:
Sample: 1 g of Anhydrous Dibasic Calcium Phosphate
Analysis: Ignite the Sample at 800C to 825C to constant weight.
Acceptance criteria: 6.6% to 8.5%
Specifications of Dibasic Calcium Phosphate BP Ph Eur Grade
Calcium Hydrogen Phosphate Dihydrate
CaHPO4-2H2O -- 172.1 -- CAS 7789-77-7
DEFINITION
Content: Dibasic Calcium Phosphate 98.0 per cent to 105.0 per cent.
CHARACTERS
Appearance: White, crystalline powder.
Solubility: Practically insoluble in cold water and in alcohol. It dissolves in dilute hydrochloric acid and in dilute nitric acid.
IDENTIFICATION
A. Dissolve 0.1 g in a mixture of 5 ml of dilute nitric acid and 5 ml of water. The solution gives reaction of phosphates.
B. 5 mg gives reaction of calcium.
C. It complies with the limits of the assay.
TESTS
Solution S: Dissolve 2.5 g in 20 ml of dilute hydrochloric acid, filter if necessary and add dilute ammonia until a precipitate is formed. Add just sufficient dilute hydrochloric acid to dissolve the precipitate and dilute to 50 ml with distilled water.
Carbonates
Shake 0.5 g with 5 ml of carbon dioxide-free water and add 1 ml of hydrochloric acid. No effervescence is produced.
Chlorides: Maximum 330 ppm.
Dissolve 0.5 g in a mixture of 1 ml of nitric acid and 10 ml of water and dilute to 50 ml with water. 15 ml of the solution complies with the limit test for chlorides.
Fluorides: Maximum 100 ppm.
Sulphates: Maximum 0.5 per cent.
Arsenic: Maximum 10 ppm.
Barium: To 10 ml of solution S add 0.5 ml of dilute sulphuric acid. After 15 min, any opalescence in the solution is not more intense than that in a mixture of 10 ml of solution S and 0.5 ml of distilled water.
Iron: Maximum 400 ppm.
Heavy metals: Maximum 40 ppm.
1 ml of 0.1 M sodium edetate is equivalent to 17.21 mg of CaHPO4-2H2O.
Specifications of Calcium Phosphate, Dibasic FCC Food Grade
Dicalcium Phosphate
CaHPO4 Formula wt, anhydrous 136.06
CaHPO4-2H2O Formula wt, dihydrate 172.09
INS: 341(ii) CAS: anhydrous 7757-93-9
CAS: dihydrate 7789-77-7
DESCRIPTION
Calcium Phosphate, Dibasic, occurs as a white powder. It is anhydrous or contains two molecules of water of hydration. It is stable in air. It is insoluble in alcohol, is practically insoluble in water, but is readily soluble in dilute hydrochloric and nitric acids.
Function: Leavening agent; dough conditioner; nutrient; yeast food.
REQUIREMENTS
Labeling: Indicate whether it is anhydrous or the dihydrate.
Identification:
A. Dissolve about 100 mg of sample by warming it with a mixture of 5 mL of 2.7 N hydrochloric acid and 5 mL of water. Add 2.5 mL of 6 N ammonium hydroxide, drop-wise, with shaking, and then add 5 mL of ammonium oxalate. A white precipitate forms.
B. Add 10 mL of ammonium molybdate to 10 mL of a warm 1:100 aqueous solution in a slight excess of nitric acid. A yellow precipitate of ammonium phosphomolybdate forms.
Assay Anhydrous or Dihydrate: Not less than 97.0% and not more than 105.0% Dibasic Calcium Phosphate.
Arsenic: Not more than 3 mg/kg.
Fluoride: Not more than 0.005%.
Lead: Not more than 2 mg/kg.
Loss on Ignition Anhydrous: Between 7.0% and 8.5%; Dihydrate: Between 24.5% and 26.5%.
SDS MSDS of Dicalcium Phosphate or Calcium Phosphate Dibasic BP Ph Eur EP JP USP NF IP ACS Analytical Reagent FCC Food grade Manufacturers |
