Crystal Clear Products Ankleshwar India
Plot No-C1-1031-9, GIDC Estate, Panoli, Ankleshwar, Gujarat - 393002. India
Telephone Mobile: 91-7506449333; e-mail: info@crystalclearproducts.org

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Sodium Picosulfate or Sodium Picosulphate Specifications of Commercial Pure & BP Ph Eur USP Grade Manufacturers & Exporters

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Sodium Picosulfate Suppliers Manufacturers
Sodium Picosulfate or Sodium Picosulphate CAS Number 10040-45-6

Sodium Picosulfate USP Grade Specifications:
C18H13NNa2O8S2-H2O --- 499.42
C18H13NNa2O8S2 --- 481.41
4,4'-(2-Pyridylmethylene)diphenyl bis(hydrogen sulfate) disodium salt, monohydrate;
Disodium 4,4'-(pyridin-2-ylmethanediyl)dibenzenesulfate
4,4'-(Pyridin-2-ylmethylene)bisphenyl bis(sodium sulfate), monohydrate CAS 10040-45-6.

DEFINITION
Sodium Picosulfate contains NLT 98.5% and NMT 100.5% of sodium picosulfate (C18H13NNa2O8S2), calculated on the anhydrous basis.

IDENTIFICATION
A. Infrared Absorption
B. Identification Tests-General, Sodium: Meets the requirements for the pyroantimonate precipitate test.

Chloride and Sulfate, Chloride: A 1.0-g portion shows no more chloride than corresponds to 0.30 mL of 0.020 N hydrochloric acid: NMT 0.02%.
Chloride and Sulfate, Sulfate: A 500-mg portion shows no more sulfate than corresponds to 0.20 mL of 0.020 N sulfuric acid: NMT 0.04%.
Organic Impurities: To pass the test by Chromatography.
Color of Solution: To pass the test.
Acidity and Alkalinity:
Analysis: To 10 mL of the portion of Sample solution retained from the test for Color of Solution add a drop of phenolphthalein.
Acceptance criteria: The solution is colorless. NMT 0.25 mL of 0.01 N sodium hydroxide is required to change the color of the indicator to pink.
Water Determination: 3.0% to 5.0%
Packaging and Storage: Preserve in tight, light-resistant containers. Store at room temperature.

Specifications of Sodium Picosulfate BP Ph Eur Grade
C18H13NNa2O8S2-H2O --- 499.4 --- CAS 10040-45-6
Action and use: Stimulant laxative.

DEFINITION
Sodium picosulfate contains not less than 98.5 per cent and not more than the equivalent of 100.5 per cent of 4,4¢-(pyridin-2-ylmethylene)bisphenyl bis(sodium sulphate), calculated with reference to the anhydrous substance.

CHARACTERS
A white or almost white, crystalline powder, freely soluble in water, slightly soluble in alcohol.

IDENTIFICATION
First identificationiA, E.
Second identificationiB, C, D, E.
A. Examine by infrared absorption spectrophotometry (2.2.24), comparing with the spectrum obtained with sodium picosulfate CRS. Examine the substances prepared as discs.
B. Examine the chromatograms obtained in the test for related substances in ultraviolet light at 254 nm. The principal spot in the chromatogram obtained with test solution (b) is similar in position and size to the principal spot in the chromatogram obtained with reference solution (a).
C. To 5 ml of solution S (see Tests) add 1 ml of dilute hydrochloric acid and heat to boiling. Add 1 ml of barium chloride solution. A white precipitate is formed.
D. To about 10 mg add 3 ml of sulphuric acid and 0.1 ml of potassium dichromate solution
R1. A violet colour develops.
E. The solution S gives reaction (a) of sodium (2.3.1).

TESTS
Solution S: Dissolve 2.5 g in distilled water R and dilute to 50 ml with the same solvent.
Appearance of solution: Solution S is clear and not more intensely coloured than reference.
Acidity or alkalinity: To 10 ml of solution S add 0.05 ml of phph solution. The solution is colourless. Not more than 0.25 ml of 0.01 M sodium hydroxide is required to change the colour of the indicator to pink.
Related substances: To pass the test.
Chlorides: Dilute 5 ml of solution S to 15 ml with water. The solution complies with the limit test for chlorides (200 ppm).
Sulphates: Dilute 7.5 ml of solution S to 15 ml with distilled water R. The solution complies with the limit test for sulphates (400 ppm).
Heavy metals: 12 ml of solution S complies with limit test A for heavy metals (20 ppm).
Water: 3.0 per cent to 5.0 per cent, determined on 0.500 g by the semi-micro determination of water.

SDS MSDS of Sodium Picosulfate or Sodium Picosulphate BP Ph Eur EP JP USP NF IP ACS Analytical Reagent FCC Food grade Manufacturers

Crystal Clear Products and the group companies are manufacturing chemicals since several decades. We have automatic vacuum operated titanium evaporators and SS316 equipments to produce top grade of chemical products. We have toll manufacturers and representatives in China, UAE, Europe, Canada & USA and agents & customers in all countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Bangkok Thailand, Kaula Lumpur Malaysia, Dubai UAE etc. & sales representative in Chicago, Houston New York & Los Angeles, USA. Associated units are FDA-GMP certified, Halal and/or Kosher certified, REACH registered, ISO-9001, ISO-22000 HACCP certified, Crisil Rated.

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Crystal Clear Products
Plot No-C1-1031-9, GIDC Estate, Panoli, Ankleshwar, Gujarat - 393002. India
Telephone Mobile: 91-7506449333; e-mail: info@crystalclearproducts.org

e-mail: info@crystalclearproducts.org

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